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KMID : 1134820120410030333
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 3 p.333 ~ p.338
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Effects of Ethanol Extract from Leaves of Eleutherococcus senticosu on Hyperlipidemia in Rats
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Park Yu-Hwa
Kim Hee-Yeon
Lim Sang-Hyun
Kim Kyung-Hee
Lee Jeong-Hoon
Kim Young-Guk
Ahn Young-Sup
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Abstract
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The effects of ethanol extract from leaves of Eleutherococcus senticosu were evaluated on hyperlipidemic rats. Male SD rats were divided into a normal group, control (AIN-76 diet) group, Garcinia cambogia extract group, and AIN-76 diet group supplemented with ethanol extract from Eleutherococcus senticosu (EEES). The body weight of the AIN-76 group increased, whereas those of the Garcinia and EEES groups decreased. The serum total cholesterol of the AIN-76 group increased by 28.36% compared to the normal group, but decreased by only 27.15% in the Garcinia group and 25.47% in the EEES group. The serum triglyceride level of the AIN-76 group increased by 35.04% compared to the normal group, but decreased by only 26.76% in the Garcinia group and 37.54% in the EEES group. The serum HDL-cholesterol levels of the Garcinia and EEES groups increased compared to that of the AIN-76 group. The liver and epididymal adipose tissue weights of the EEES group decreased compared to those of the AIN-76 group. In measuring the concentration of triglycerides and total cholesterol level in the liver extracts, the AIN-76 group showed significant increases compared to the normal group, whereas the Garcinia and EEES groups showed a significant decrease compared to the AIN-76 group. These results indicate that the EEES group may improve lipid metabolism and reduce fat accumulation and body weight.
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KEYWORD
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Eleutherococcus senticosu, anti-obesity effect, hyperlipidemic
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